Cushing’s Disease (also known as hyperadrenocorticism) is one of those conditions that often goes unnoticed until it's already had a major impact on a dog’s health and quality of life. In this guide, we’ll break down everything you need to know — the symptoms, causes, treatment options, and everyday care — with insights you won’t find on every pet blog.
We’ll also explore the connection between Cushing’s Disease and mobility problems, and how supportive tools like dog wheelchairs can help affected dogs stay active and happy.
What Is Cushing’s Disease in Dogs?
Cushing’s Disease occurs when a dog’s body produces too much cortisol — the "stress hormone." Cortisol helps regulate metabolism, blood sugar, inflammation, and the immune response. But when there’s too much of it for too long, the body starts to break down.
There are two main types:
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Pituitary-dependent Cushing’s (most common – around 80-90% of cases): caused by a benign tumor on the pituitary gland in the brain.
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Adrenal-dependent Cushing’s: caused by a tumor on one of the adrenal glands above the kidneys.
There’s also a third, less discussed type: iatrogenic Cushing’s, caused by long-term use of corticosteroid medications.
Recognizing the Signs: Not Just “Getting Older”
Cushing’s can mimic normal signs of aging — which is why it’s often missed or misdiagnosed.
Here are both the typical and the more subtle signs to watch for:
Common symptoms:
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Increased thirst and urination
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Increased appetite (but without weight gain)
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Hair loss, especially on the body (not head/legs)
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Thinning skin, easy bruising
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Pot-bellied appearance
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Panting more often, even at rest
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Lethargy
Less obvious symptoms:
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Muscle wasting — which can lead to mobility problems
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Loss of interest in walks or play
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Skin infections that won’t go away
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Behavior changes — restlessness, confusion
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Incontinence
If your dog is showing these signs, especially in combination, a trip to the vet is crucial. Early detection makes a massive difference.
How Is Cushing’s Diagnosed?
This part can be tricky. There’s no single test that 100% confirms Cushing’s.
Veterinarians often use:
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ACTH stimulation test
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Low-dose dexamethasone suppression test (LDDS)
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Ultrasound of the adrenal glands
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Blood pressure and urine cortisol:creatinine ratios
These tests can be expensive — but without them, it’s nearly impossible to differentiate between types of Cushing’s or rule out similar conditions like diabetes or hypothyroidism.
Why Untreated Cushing’s Can Be Dangerous
Cushing’s isn’t just about drinking too much water or looking a bit pudgy. If left untreated, it can lead to:
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Muscle loss and mobility issues
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High blood pressure
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Increased risk of diabetes
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Pancreatitis
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Kidney damage
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Increased risk of infections and poor wound healing
In short: quality of life steadily declines — both for the dog and the owner.
Mobility and Muscle Wasting: The Overlooked Side Effect
Dogs with Cushing’s gradually lose muscle tone, especially in the hind legs. Many begin to struggle with stairs, walks, or even standing up.
Not many people realise this, but mobility support can radically improve a dog's life with Cushing’s.
Supportive tools like Furria's small dog wheelchair allow dogs to regain independence, reduce joint strain, and stay mentally engaged.
Even short daily outings in a wheelchair can:
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Stimulate appetite
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Reduce depression and anxiety
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Help maintain healthy digestion
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Improve sleep patterns
Treatment Options: What Really Works?
1. Medication
The most common treatment is oral medication. Options include:
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Trilostane (Vetoryl) – Most commonly prescribed. Inhibits cortisol production.
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Mitotane – Older, more aggressive drug. Used in severe cases.
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Selegiline (Anipryl) – Occasionally used for pituitary-dependent Cushing’s.
Medication isn’t instant. It may take weeks or months to balance hormone levels and improve symptoms.
2. Surgery
In cases of adrenal-dependent Cushing’s, removing the adrenal tumor can be curative — but it's risky, costly, and typically reserved for otherwise healthy dogs.
3. Radiation
For pituitary tumors (especially in large breeds), radiation may be used when medication fails.
Day-to-Day Management at Home
Whether your dog is in treatment or not, your care can make a big difference.
Diet & Nutrition
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Avoid high-fat foods — dogs with Cushing’s are at higher risk for pancreatitis.
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Focus on lean proteins, anti-inflammatory foods, and low-glycemic carbs.
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Add omega-3 fatty acids (with vet approval).
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Consider supplements like SAMe or milk thistle for liver support.
Mobility & Comfort
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Use rugs or mats to help with traction on slippery floors.
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Consider supportive harnesses or wheelchairs.
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Keep nails trimmed — overly long nails increase instability.
Skin & Coat Care
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Bathe with medicated shampoos (consult your vet first).
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Check for signs of skin infections or wounds.
Is Cushing’s Curable?
In some cases, yes — especially with adrenal tumors that are surgically removed. But for most dogs, Cushing’s is managed rather than cured.
That said, many dogs live happy, active lives for years after diagnosis — especially with proper treatment, love, and mobility support.
Final Thoughts: Don’t Ignore the “Little” Changes
Cushing’s Disease often creeps in slowly. What starts as a little extra panting or thirst can be a sign of something deeper.
Early diagnosis, regular vet check-ups, and the right tools — including mobility support — can dramatically improve your dog’s comfort and longevity.
If your dog is showing signs of weakness or muscle loss, don’t wait. Explore our supportive solutions like Furria’s Small Dog Wheelchair and see what a difference freedom of movement can make.
